14 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Jul 4th 2026
ReturnsSat, Jul 18th 2026
Nights14
Departing PortPittsburgh
Ports of CallPittsburgh, Marietta, Maysville, Cincinnati (2 Days), Louisville (2 Days), Henderson, Evansville, Paducah, Cape Girardeau, St Louis (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate… 
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Jul 4th 2026
ReturnsSun, Jul 12th 2026
Nights8
Departing PortPittsburgh
Ports of CallPittsburgh (2 Days), Moundsville, Marietta, Maysville, Cincinnati, Louisville (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Jul 11th 2026
ReturnsSun, Jul 19th 2026
Nights8
Departing PortLouisville
Ports of CallLouisville, Cincinnati, Maysville, Marietta, Moundsville, Pittsburgh (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Jul 18th 2026
ReturnsSun, Jul 26th 2026
Nights8
Departing PortPittsburgh
Ports of CallPittsburgh (2 Days), Moundsville, Marietta, Maysville, Cincinnati, Louisville (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
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Ocean View
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Balcony
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Suite
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Jul 25th 2026
ReturnsSat, Aug 1st 2026
Nights7
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Red Wing, La Crosse, Dubuque, Davenport, Kingston, Fort Madison, St Louis
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Melody
DepartsSat, Jul 25th 2026
ReturnsSun, Aug 2nd 2026
Nights8
Departing PortLouisville
Ports of CallLouisville, Cincinnati, Maysville, Marietta, Moundsville, Pittsburgh (2 Days)
American Cruise Lines is pleased to announce the newest ship in our revolutionary series of modern riverboat series. American Melody will begin its inaugural season on the Mississippi River in the summer of 2021 and was specifically designed to navigate…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
